The Scheele lab is located at the VIB Center for Cancer Biology in KU Leuven, which is located in the University Hospital Campus, Leuven, Belgium. We are a young research team that studies the dynamics of tumor progression using cutting-edge imaging technologies, such as whole organ 3D imaging and high-resolution intravital microscopy. We combine these imaging techniques with the latest genetic mouse models, organoid culture systems, and single cell technologies.
Using these techniques, we previously studied the intricate process of organ development in branched organs, such as the mammary gland and the kidney (Scheele et al., Nature 2017; Hannezo et al., Cell 2017). We uncovered the location and number of the stem cells that drive mammary gland development and were able to visualize stem cell behavior and dynamics for the first time in vivo.
Now that we understand the basic principles that drive branched organ formation, we will take it a step further and disentangle the dynamics of failure of these organs due to genetic defects, tissue damage, or mutation accumulation and subsequent tumor formation.Job description
You will study the dynamics of tumor initiation and progression using advanced microscopy technologies, genetic mouse models, PDX models, and organoid cultures. You will be in charge of your own research project, but you should also be willing to work as part of a team. We strongly value a collaborative and sharing scientific environment.Profile
Please send your application via the online tool. For more information on the position, you can contact Dr. Colinda Scheele.
Applications should include a motivation letter, detailed CV, and at least two contacts for further references.